Category Archives: Immunology

Interleukin-6

The earliest alarming for sepsis

Every minute and every second, the medical team had always encountered challenges. The clinicians kept thinking about how to detect a baby’s condition earlier and how to reduce antibiotics administration. Interleukin-6 acts as a pro-inflammation cytokine and a key mediator of inflammation. During the acute phase of infection, B and T lymphocytes are stimulated to produce the Interleukin-6 cytokine, which in turn induces hepatocyte production of acute-phase reactants such as CRP.

With these characteristics, the Interleukin-6 could help to detect EOS(Early Onset Sepsis) earlier and can work as a complementary function with existing tests such as CRP(C-Reactive Protein) and PCT(Procalcitonin). Boditech Med has launched the AFIAS Interleukin-6 in September 2020, and it has been landed successfully. It is expected that the AFIAS Interleukin-6 test aid to detect inflammation in the early stage and will contribute to improving the newborn’s health.

Interleukin-6, an essential test for NICU and children’s hospital

1. Early Onset Sepsis occurs within 72 hours of life

Neonatal sepsis is a major contributor to morbidity and mortality in neonates, especially in those born preterm. The Global Burden of Disease (GBD) estimated 1.3 million annual incident cases of neonatal sepsis and other infections 2,874 sepsis cases per 100,000 live births and a mortality of 17.6%.

2. Exposure to inappropriate and/or excessive antibiotic use

Antibiotics are the most commonly prescribed class of medications in the NICU. The probability of EOS combined with the clinical instability characteristic of premature newborns leads to high rates of empirical antibiotic treatment. previous studies demonstrate that neonatal clinicians administer antibiotics from birth in 79% to 98%.

3. C-tip is the ideal method for infants’ or children’s sample collection

An infant’s blood collection cannot exceed 1% of body blood, usually premature baby is under 2 kg therefore, 1 ml for once is maximum. The research shows, that 51.7% of hospitals in Korea collect 0.5 ml, and 24.1% collect 1 ml from an infant’s heel for a blood culture test. It is already in the dangerous range for infants.

NICU clinicians need the method to improve diagnostic capabilities, which can provide reliable results, early and rapid, simple and safely in the patient’s bedside or in the ICU.

AFIAS parameters

ichroma parameters